Juq-565 Official

| Parameter | Mouse | Rat | Human (in‑vitro) | |-----------|-------|-----|------------------| | Kinetic solubility (µM) | 38 | 33 | 41 | | Microsomal t₁⁄₂ (min) | 45 | 38 | 52 | | Plasma protein binding (fu) | 0.12 | 0.10 | 0.15 | | Oral F (mouse) | | 55 % | — | | Cmax (µM) after PO 30 mg kg⁻¹ | 6.8 | — | — | | AUC₀‑∞ (µM·h) |

[ \lvert\Phi_d\rangle = \frac1\sqrtd \sum_k=0^d-1 \lvert k\rangle_A \lvert k\rangle_B, ]

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Recombinant human PI3Kα, β, γ, δ (Carna Biosciences) were incubated with PIP₂ substrate and ATP in the presence of increasing concentrations of JUQ‑565 (0.01 nM – 10 µM). Reaction products were quantified using a luminescent ADP‑Glo assay (Promega). IC₅₀ values were derived by four‑parameter logistic fitting (GraphPad Prism 9).

Content associated with codes like JUQ-565 is generally distributed through authorized domestic Japanese digital platforms, physical DVD retailers, and global adult media databases. In digital indexing, these specific alphanumeric strings serve as critical metadata tags, ensuring users can accurately locate specific titles across thousands of daily updates without translation errors. Share public link | Parameter | Mouse | Rat | Human

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